Arieh Moussaieff
Hebrew University, Israel
Title: Cell-type metabolic analysis: A new tool for understanding metabolic heterogeneity
Biography
Biography: Arieh Moussaieff
Abstract
Metabolic profiling provides a highly sensitive phenotype. Until recently, such analyses were performed on whole organisms or tissues or on cell cultures, providing scarce cell-specific information. This work investigates several aspects of cell-type metabolism. A metabolic map of a tissue was drawn using the Arabidopsis root as a model for cell-type metabolic analysis and a new protocol was developed, providing cell-specific metabolic profiles within a tissue. This protocol is now pursued for the cell-type analyses of developmental and cancerous processes. New insights into metabolic zonation and metabolic regulation of cell fate will be discussed.