Founded in Darmstadt in 1668, Merck is the world’s oldest pharmaceutical and chemical company. Merck’s portfolio of analytical products and services recently saw a significant expansion by the acquisition of the Sigma-Aldrich company (including the Supelco brand), and now includes, among others, products for sample preparation, chromatography columns and accessories, reagents, standards, and reference materials. A large proportion of the HPLC columns are suitable for LC-MS applications, and are specially developed for such areas of use. The well-known families of columns include, among others, the ZIC-HILIC, Purospher STAR, Chromolith (monolithic columns), Ascentis Express, and BIOshell (fused core) in their number. Numerous methods and applications from the broadest conceivable range of analytes – for example biomarkers, pharmaceutical compounds, proteins and peptides, and pesticides – have been developed using these columns and are available online,. Merck offers a comprehensive portfolio for HPLC applications, covering the entire spectrum of processes from sample preparation, via separation, all the way to calibration. We are also glad to offer you technical support and guidance in your method development processes. For more details follow the link: http://www.sigmaaldrich.com/